The following is a list of recurring and semi-recurring characters (meaning, those featured as guests in at least 2 episodes) who, at the time of their introduction in the series, were acquaintances of Bree Van de Kamp, one of its protagonists. Minor unnamed characters, such as nurses, police officers, etc., may not be included. Characters that belong to Bree's family are also not included, even if they aren't actually related to the character. The list also includes characters who aren't necessarily acquainted with Bree, but with her family members and/or romantic interests at the time of the characters' introduction.

Season 1 introduced acquaintances

• Dr. Albert Goldfine - A therapist whom Bree and Rex sought out to help them reconcile. Goldfine eventually handled topics such as their troubled sex life, and even helped Bree after she became a widow; he was last seen after his attack at the hands of George Williams.
• Tish Atherton - A local rich woman and gossip, Tish was a formal acquaintance of Bree's and a member of the local country club, who helped spread the news of Maisy Gibbons' arrest and who snubbed Bree after she refused to listen to her friend Carolyn Bigsby's claims that Orson had killed his first wife.
• Reverend Sikes - A Presbyterian reverend who often serves as Bree's confident. He was called over for dinner with the Van de Kamps after Andrew announced that he was a homosexual, he served as the minister at Rex's funeral, he wed Bree and Orson, and he tried to get Bree to bond with the lonely Beth Young.
• Dr. Lee Craig - A physician who worked at Fairview Memorial Hospital. He was Ida Greenberg's nephew, and a formal acquaintance of Bree and Rex Van de Kamp, as well as the latter's co-worker. He warned Rex that he may have been poisoned by Bree, and he served as Mike Delfino's physician after he was hit by a car.

Season 2 introduced acquaintances

• Detective Barton - The detective in charge of the case of Rex's death. He believed Bree to have been the murderer, and once that was all sorted out, she asked him out for lunch to get some dirt on the Applewhites, but Barton misinterpreted her, and got angry once he found out she wasn't interested in dating him.
• Detective Sloan - A detective working on the case of Rex's death, who was present when Bree was called over to George's house after it had been determined that he was the killer.
• Samuel Bormanis - A lawyer Andrew hired to help him get emancipated, so he could access his trust fund sooner than intended.
• Amanda - A seemingly catatonic woman who Orson often visited at the local psychiatric center, where he was more casually introduced to Bree.
• Dr. Barr - Bree's shrink at the psychiatric center, a man who tried to get her to open up about her problems and who refused to believe her when she claimed that her daughter had run off with a murderer.

Season 3 introduced acquaintances

• Carolyn Bigsby - Orson's nosy ex-neighbor and Alma's good friend, who always assumed she'd been murdered by her husband. Carolyn "hosted" a hostage takeover at the local supermarket when she found out her husband, the manager, had cheated on her.
• Monique Polier - Orson's mistress, a French stewardess who was also sleeping with Harvey Bigsby, and who wound up murdered.
• Detective Ridley - The detective in charge of Monique Polier's murder case, who strongly suspected Mike Delfino was the culprit.
• Jerry - A coroner who worked with Ridley on Monique's case, and who unveiled her body for Orson Hodge to identify.
• Robert Falati - Danielle's History teacher, with whom she was sleeping. Mr. Falati was threatened by Bree to leave Danielle, and when he did, the Van de Kamp girl ruined his life.
• Harvey Bigsby - Carolyn's cheating husband, the manager of a local grocery store, who used to be Orson's best friend.

Season 4 introduced acquaintances

• Michelle Downing - A local socialite and formal acquaintance of Bree's, who hosted several galas and parties during the social season.

Season 5 introduced acquaintances

• Bruce - Bruce was Bree's book publisher, an obnoxious man who often mocked Orson during their first encounter, and who would record his ideas. He interviewed both Tom and Lynette Scavo, and hosted the reception for Bree's possible second cookbook.
• Dr. Bernstein - The shrink that tries to help Orson overcome his kleptomania.
• Rose Kemper - An elderly woman on the lane who almost got robbed by Orson, wearing a ski mask. Rose whacked him over the head with a baseball bat and fainted after she saw Edie Britt crashing her car. She was admitted into a nursing home after Orson told the doctor she wasn't stable.

Season 7 introduced acquaintances

• Mary Wagner - Keith Watson's mother, a gynecologist who has a bit of a drinking condition, and whose relationship with her husband was strained after he came home from the army for goo.d
• Richard Watson - Keith's father and Mary's ex-husband, an army veteran whose wife grew tired of quarreling with. He developed a fancy on Bree and made a pass at her, something she and Keith didn't take well.
• Amber James - Keith's ex-girlfriend, who came back to Fairview looking for him, to tell him about their son, Charlie.
• Charlie - A mixed-raced young boy who was fathered by Keith, Bree's contractor ex-boyfriend. Keith left Fairview and his girlfriend to be closer to Charlie.