Bree Van de Kamp - Coined as "Martha Stewart-on-steroids", the matriarch of the family is a neurotic and perfectionist home fairy who drives her family crazy. She has been widowed and divorced and currently married again. She married a doctor (Rex), a dentist (Orson), and a lawyer (Trip). She was also engaged to a lawyer (Karl).
Rex Van de Kamp - Bree's first husband, a doctor whom she was married to for 18 years until he was poisoned by their pharmacist. Rex was into S&M sex. Bree was not. Rex is the father of Bree's two kids and her stepson.
Orson Hodge - Bree's second husband, a dentist with a shady past who wound up developing an affiliation for kleptomania and lying, drove her to an affair, and then left her while a paraplegian. After a 9 year rocky marriage, Orson leaves Bree in the season six finale for being a hipocrit but attempts to win her back twice but fails.
Trip Weston - Bree's third husband, a defense attorney who represented her when she was charged with the murder of Alejandro Perez. When the pair relocated to Louisville, he convinced Bree to enter into politics.
Andrew Van de Kamp - The first born child, Andrew is a homosexual sociopath who went out of his way to destroy his mother, until he eventually learnt to grow up. Andrew was briefly married to Alex Cominis from seasons five to seven and cheated on him in season six.
Danielle Van de Kamp - Bree's obnoxious and self-centered daughter, who never truly grew up. Danielle has a son with Edie Britt's nephew. Bree and Orson adopt her son and raise him as their own for three years until Danielle marries and takes him away. Danielle and her husband Leo divorce however after a few years.
Benjamin Katz - Danielle's son, who posed as Bree's son for a short period of time, until the birth mother took him back. He is the biological son of Austin McCann and the former stepson of Leo Katz.
Sam Allen - Rex's illegitimate son, who wanted to belong to the Van de Kamp family all his life, until eventually he blackmailed his way out of it.
Henry Mason - Bree's father, a conservative lawyer, who wanted to take Andrew to live with him after his emancipation suit. He cheated on Bree's mother before she died.
Mrs. Mason - Bree's mother, a homemaker, who trained her daughter to repress her emotions. She later died on the night of Christmas Eve, and her blood was scrubbed off the street by her daughter. Her husband was revealed to have cheated on her when Bree was a kid.
Eleanor Mason - Bree's step-mother, a relatively cold woman who discouraged Henry of taking Andrew with them when she found out he was gay.
Unnamed Grandmother - Bree's grandmother, she said to Bree that sex is "a woman's burden". Bree's grandmother gave Bree her good china when she died and this is why Bree pretended to love her.
Phyllis Van de Kamp - Rex's mother, who was deeply affected by his death and who had a tough relationship with her daughter-in-law.
Mr. Van de Kamp - Rex's deceased father and Phyllis's husband.
Gloria Hodge- Orson's mother, a religious fanatic responsible for the deaths of his father and mistress, and who suffered a paralyzing stroke.
Edwin Hodge - Orson's father and Gloria's adulterous husband, whom she murdered and made it seem like a suicide.
Alma Hodge - Orson's first wife, a crazy woman who was devoted to him and often acted as Gloria's "puppet".
Alex Cominis - Andrew's ex-husband, a plastic surgeon that fixed Orson's broken nose and left Andrew after he became an unbearable alcoholic.
Melina Cominis - Alex's annoying mother, who rivaled Bree for the title of "perfect mother-in-law".
Leo Katz - Danielle's ex-husband, an environmentalist lawyer who adopted Benjamin, but who apparently walked out on the family, for unspecified reasons.
Lillian Allen - Sam's mother, who had a one night stand with Rex and didn't allow her son to live with the Van de Kamps.
Fern - Bree's aunt, who told her niece at her first wedding, to Rex, to believe that the best was yet to come whenever things looked troubling. Fern has glaucoma and made a toast at Bree's second wedding; she lives in Philadelphia.
Ty Grant - Bree's first fiancé, whom she dumped to be with Rex. They met again 20 years later.
George Williams - A seldom psychotic pharmacist who was unlucky in love and thus developed an unhealthy obsession with the first woman that gave him a break: Mrs. Van de Kamp. He has had two fiancee's leave him for being insane- Leila Mitzman and Bree Van de Kamp.
Keith Watson - Bree's younger contractor boyfriend; the age difference between them provided the most obstacles in their relationship.
Chuck Vance - Bree's detective boyfriend, whom she broke up with to protect her biggest secret yet. However, Chuck eventually caught on that something was wrong, and his thirst for revenge took the best of him.
Mary Beth - Andrew's billionaire fiancée who he wanted to marry to get help with his numerous financial problems.
Justin - Andrew's first boyfriend, whose parents kicked him out and who would often sleep over at the Van de Kamp house.